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Cell’s Lament

(To the tune of “Yesterday”) / Recording by Tim Karplus

Woe is me
My substrates are losing entropy
Causing gains in Gibbs free energy
Oh I can’t lose no en – tro- py

Re-a-lly
I could use a source of enthalpy
To combat the rise in Delta G
Oh I believe in enthalpy

I crave en-er-gy
Don’t you see?
It’s getting worse

My re-actions all
Soon will stall
And then rever-r-r-se

ATP
It’s the metabolic currency
Guess I’ll spend a bit judiciously
To help reduce the Delta G
Help reduce the Delta G

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Transcription

(To the tune of “Frosty the Snowman”)

Phos-pho-di-esters
Are the bonds of RNA

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(To the tune of “Twinkle, Twinke Little Star”)

Lysine, arginine and his
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(To the tune of “Those Were the Days, My Friend”)

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The time was ripe for it to split in two

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(To the tune of “When Johnny Comes Marching Home”)

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Are oxidized inside the mi-to-chon-dri-ay

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To say a fond goodbye
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With our colleague Dr. Frei

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(To the tune of “You’re Sixteen”)

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(To the tune of “Moon River”)

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