(To the tune of “Santa Claus is Coming to Town”) / Recording by Tim Karplus
You’ve gotta admire
What molecules do
Their cellular fire
Is ready on cue
Glucagon is coming around
If hormone should bind
Receptor outside
G protein finds
G nucleotides
Glucagon is coming around
They activate cyclases
That make cAMPs
Which bind to protein kinases
And pull the R’s from C’s
The glycogen shrinks
In liver quite fast
The glucose into
The bloodstream is passed
Thanks to this you have energy
Your muscles uptake
The glucose in turn
Obtaining a substrate
That all of them burn
Thanks to this you have energy
The pool of phosphatidyl
Inositides in you
Can send two separate signals
When they get split in two
The IP3 sets
The calcium free
Turning on
Protein Kinase C
And it happens so easily
The muscles contract
When calcium’s free
Lowering levels
Of Creatine-P
And it happens so easily
Those little calcium ions
I hope you’ve learned them well
Are just like Martha Stewart
All locked up in a cell
This story’s complete
I know it’s a load
My hope is your head
Ain’t gonna explode
You will need it in finals week
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