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Heme

(To the tune of “Jean”)

Heme, heme, colored supreme
Deepest red I’ve ever seen
When my oxygen’s low
Hemoglobin will know
Give up oxygen, heme

Heme, heme porphyrin ring
Bonded to five histidines
When an oxygen binds
To your iron it climbs
Tugging histidine, heme

Then the globin arranges itself a new way
And the three other units tell their hemes OK
They can go on a bindin’ – oh-two they’re findin’

Then heme, heme leaving the lungs
Travels inside the bloodstream
When it finds a tissue
That is lacking oh-two
It gives what it needs, bloody heme

Heme, you keep me alive
Binding coop’ratively
Go release what I need
Christian Bohr has decreed
Tissues adore you, lovely heme

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_x000B_From five prime to three prime, translation, translation_x000B_The final step that we know about the central dog-ma_x000B_Amino, carboxyl, translation, translation. . . ._x000B_Translation, translation, translation . ._x000B_

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