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Three R’s of DNA

(To the tune of “Dream a Little Dream of Me”)
Recording by Liz Bacon and David Simmons

Base pairs they all provide you
Stair steps to form a helix inside you
A pairs with T and G goes with C
Making DNA for me

Helicases go unwinding
Unzippering at rates almost blinding
PO-lymerases work night and day
Replicating D-N-A

(Bridge)
Proof-reading – the enzyme’s Q/C path
Chews back from the 3’s
I can’t have a ‘G’ paired with ‘T’ so
Repair it please

Chem damage is concern too
‘Cuz it can cause mutations inside you
When dimers stem from sunlight UV
Fix the DNA for me

Such pathways of excision
Cause cells to have to make a decision
Should they go straight ahead with repair
Or take themselves right out of there?

(Bridge)
Then lastly, there’s recombination
Swap strands readily
Crossover homologous regions
Mix them for me

This story is complete now
The DNA is fit for gametes now
The three R’s for our DNA shine
Replicate, repair, recombine
(Oh yeah!)
Replicate, repair, recombine

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How about these?

B-DNA

PhosphatesAre in nucleotidesI say phosphatesCover bases insideI say phosphatesSpan the 5 and 3 primesThere’s no need-to-be-all-mixed-up
BasesCarry info you seeI say basesAre all complement’ryI say basesLike A,T,G and CThey have got-to-be–all-paired-up
It’s fun to play with some B-DNAIt’s got a boatload of G-C-T-AIt’s got everythingA polymerase needsWhen you melt all the A’s and T’s
It’s fun to play with some B-DNAIt’s got a boatload of G-C-T-AYou can make RNAsWith a po-ly-mer-aseJust by pairing up U’s with A’s

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