I Wanna Hold Your Strands

(To the tune of “I Wanna Hold Your Hands”)

Oh yeah, I’ll tell you something
It helps to understand
Pol III de-crees
To meet the cell’s demands
It has to hold the straaaaaands
It’s gotta hold the strands

The key, Pol III
Acts most processively
‘Cuz see, Pol III
Has beta clamping ha-a-a-a-ands
It uses beta’s ba-a-a-a-a-a-ands
To hold onto the strands

As it starts rep-li-CAT-ING a d—N-A
The un-win-DING requires a lone
Helicase
Helicase
Helica-a-a-a-a-a-a-ase!

Pri-mase starts the primer
That Pol I can erase
Pol III takes the primer
And starts the DNAs
It starts the DNA-a-a-a-as
By using RNA

And when a fragment Okazaki – displays
There must be joining
That requires
A ligase
A ligase
A liga-a-a-a-ase

Thanks to all the factors
And all of their ligands
The cell has what matters
To replicate the strands
It replicates the strands
It replicates the strands
It replicates the stra-a-a-a-a-a-a-a-ands